Genetics of DNA Methylation Consortium
GoDMC was established with the view of bringing together researchers with an interest in studying the genetic basis of DNA methylation variation, to consolidate as many resources and expertise as possible and thereby expedite this field of research.
Aims and Objectives
With this in mind the following aims and objectives have been set out:
- To encourage collaborations for rapid large-scale replication and meta-analyses following a conventional genome-wide association study (GWAS) consortium structure
- To provide an online forum to publicise potential data sources and on-going projects
- To prioritise the analysis of Illumina HM450 BeadChip and GWAS data, in the first instance (Other bisulphite modified DNA methylation data will be included in due course)
- To include all tissue types and disease/phenotypic subgroups.
Achievements so far
To date, GoDMC comprises representatives from 22 research groups. Together these groups have the potential to contribute data from multiple sources including a range of population, birth and disease specific cohorts, capturing a range of ages and ethnic backgrounds. Details on these cohorts can be found here.
As the aim of GoDMC is to support and expedite research within the field of epigenetics, all members are encouraged to establish and lead their own analysis projects; either genome-wide meta-analyses or targeted replication studies. It is intended that all GoDMC members will be jointly involved with no single group or individual dominating. Five broad project areas have been set out and a number of projects within these areas have already been proposed. For details on how to join GoDMC and its ongoing activities or how to propose new projects please see the Information page.
Executive & Steering Committees
Executive & Steering Committees have been established to oversee the development and management of GoDMC. Led by Professor Caroline Relton, the Executive Committee comprises:
Prof. Caroline Relton, Dr. Jordana Bell, Dr. Christoph Bock, Dr. Bas Heijmans and Prof. Jonathan Mill
The Steering Group comprises:
Prof. Andrea Baccarelli, Prof. Stephan Beck, Prof. George Davey Smith, Prof. Mark McCarthy, Prof. Peter Visscher and Dr. Nicole Soranzo